Clinton, a former first lady running to become the nation's first female president, laughed at the seemingly sexist protest that suggested a woman's place is doing the laundry and not running the country.

"Ah, the remnants of sexism—alive and well," Clinton said to applause in a school auditorium.

The two men were removed from the hall after raising a pair of signs that said, "iron my shirt!" They also shouted the same slogan.

"Can we turn the lights on? It's awfully dark," Clinton said, cueing the lights to come and police to come forward take the men away.

The overflow crowd burst into applause and some began shouting, "Iron my shirt" as the two were taken from the hall.

"As I think has been abundantly demonstrated, I am also running to break through the highest and hardest glass ceiling," she said.

Clinton later joked about the incident as she invited questions.

"If there's anyone left in the auditorium who wants to learn how to iron a shirt, I'll talk about that," Clinton said with a smile.

Clinton placed a disappointing second place in Iowa's caucuses last week and now faces a tough challenge here from Barack Obama, who leads her with just one day remaining.

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