Rendell said Catherine Baker Knoll died at National Rehabilitation Hospital in Washington, D.C., where she had been recovering from the treatments.
Knoll, was the first woman elected as the state's lieutenant governor. She was diagnosed with neuroendocrine cancer in July and began radiation and chemotherapy treatments.
She returned for the start of the fall Senate schedule in September. But she showed signs of fatigue and said later that month she would take time off at the advice of doctors and family.